OncoScreen is a cancer genetic (CGx) test that helps identify a person's inherited risk of developing certain types of cancer.
Cancer is a genetic disease.
It is caused by genetic changes to genes that control the way our cells function, especially how they grow and divide. While many cancer-causing genetic changes (mutations) can be acquired during one's lifetime, some of the genetic changes can be inherited from our parents.
Genetic testing from a saliva sample may identify inherited genetic mutations that can increase a person's lifetime risk for certain types of cancer.
About 5%-10% of all cancers result from inherited gene defects.
American Society of Clinical Oncology (ASCO)
ASCO recommends that genetic testing be offered to individuals with suspected inherited (genetic) cancer risk in situations where test results can be interpreted, and when they affect medical management of the patients. Adapted from Journal of clinical Oncology 2015.
Who is eligible to be tested?
According to the national comprehensive cancer network genetic testing for hereditary cancer should be considered if a patient or their family members meet any of the following criteria:
3 or more cancer on the same side of the family.
2 or more primary cancers in the same person.
Early diagnosis ( ≤ 50 years old) of breast, colorectal or uterine cancer.
Of Ashkenazi Jewish descent and history of breast, ovarian or pancreatic cancert at any age.
A blood relative with breast cancer.
10 or more colorectal plyps in a person's life time.
Hereditary Cancer Gene Tests
The OncoScreen test includes a panel of 94 genes suspected to play a role in predisposing patients to cancer, including genes associated with common and rare cancers such as:
About 1 in 12 U.S. men (about 8% will be diagnosed with prostate cancer in his lifetime.
About 1 in 8 U.S. women (about 12.4% will develop invasive breast cancer over the course of her lifetime.
Why is genetic testing for cancer predisposition important?
Genetic testing can help identify genetic mutations that can increase your risk for certain cancers. This can help your healthcare provider:
Modify the frequency and initial age of mammogram/breast MRI, colonoscopy, prostate cancer screening or other surveillance strategies.
Discuss prevention options such as chemoprevention, prophylactic mastectomy, colectomy, prophylactic oophorectomy or other risk reducing interventions.
Identify other at-risk family members.