We are excited to share this important work by Sørbye et al. “Performance of a 7-Type HPV mRNA Test in Triage of HPV DNA Primary Screen Positive Women Compared to Liquid-Based Cytology”
A new study, nested in the real HPV-DNA primary screening in North Norway, presents evidence that a 7-type HPV mRNA test is a more precise risk stratification tool among HPV-infected women compared to liquid based cytology (LBC).
Evidence was presented that mRNA detection from the seven HPV types (16, 18, 31, 33, 45, 52, 58) represented a significantly higher risk of CIN2+ (29.0%) compared to LBC.
Presented data confirmed the 7-type HPV mRNA test to be significantly more specific than cervical cytology (71.0% versus 47.8%), reducing the number of colposcopies while keeping the same sensitivity towards the detection of CIN2+.
Using this biomarker as the threshold for colposcopy may better balance the benefits and harms of screening.
You can read the full text here: https://www.mdpi.com/2673-5261/4/2/8